What is the Research saying?

Hyperbaric oxygen therapy (HBOT) has garnered significant attention across various medical disciplines. Here are rearranged citations from studies exploring its mechanisms and applications:

Mechanisms of HBOT:

  1. Wingelaar TT, Brinkman P, van Ooij PJAM, et al. Markers of Pulmonary Oxygen Toxicity in Hyperbaric Oxygen Therapy Using Exhaled Breath Analysis. Front Physiol. 2019;10:475. Published 2019 Apr 24. doi:10.3389/fphys.2019.00475

  2. Bhutani S, Vishwanath G. Hyperbaric oxygen and wound healing. Indian J Plast Surg. 2012;45(2):316–324. doi:10.4103/0970-0358.101309

  3. Thom SR. Hyperbaric oxygen: its mechanisms and efficacy. Plast Reconstr Surg. 2011;127 Suppl 1(Suppl 1):131S–141S. doi:10.1097/PRS.0b013e3181fbe2bf

  4. Thom SR. Oxidative stress is fundamental to hyperbaric oxygen therapy. J Appl Physiol (1985). 2009;106(3):988–995. doi:10.1152/japplphysiol.91004.2008

  5. A.L. Gill, C.N.A. Bell, Hyperbaric oxygen: its uses, mechanisms of action and outcomes, QJM: An International Journal of Medicine, Volume 97, Issue 7, July 2004, Pages 385–395, https://doi.org/10.1093/qjmed/hch074

HBOT and General Health:

  1. Vadas D, Kalichman L, Hadanny A, et al. Hyperbaric oxygen environment can enhance brain activity and multitasking performance. Front Integr Neurosci. 2017;11:25. Published 2017 Sep 27. doi:10.3389/fnint.2017.00025

  2. Fife CE, Eckert KA, Carter MJ. An update on the appropriate role for hyperbaric oxygen: indications and evidence. Plast Reconstr Surg. 2016;138(3 Suppl):107S–16S. doi:10.1097/PRS.0000000000002714

  3. Fujita N, Ono M, Tomioka T, et al. Effects of hyperbaric oxygen at 1.25 atmospheres absolute with normal air on macrophage number and infiltration during rat skeletal muscle regeneration. PLoS One. 2014;9(12):e115685. Published 2014 Dec 22. doi:10.1371/journal.pone.0115685

  4. Thom SR. Oxidative stress is fundamental to hyperbaric oxygen therapy. J Appl Physiol (1985). 2009;106(3):988–995. doi:10.1152/japplphysiol.91004.2008

  5. Hink J, Jansen E. Are superoxide and/or hydrogen peroxide responsible for some of the beneficial effects of hyperbaric oxygen therapy? Med. Hypotheses, 57 (6) (2001), pp. 764-769.

HBOT and Infection:

  1. Ciofu O, Tolker-Nielsen T. Tolerance and resistance of Pseudomonas aeruginosa biofilms to antimicrobial agents-how P. aeruginosa can escape antibiotics. Front Microbiol. 2019;10:913. Published 2019 May 3. doi:10.3389/fmicb.2019.00913

  2. Kolpen M, Lerche CJ, Kragh KN, et al. Hyperbaric oxygen sensitizes anoxic Pseudomonas aeruginosa biofilm to ciprofloxacin. Antimicrob Agents Chemother. 2017;61(11):e01024-17. Published 2017 Oct 24. doi:10.1128/AAC.01024-17

  3. Gade PAV, Olsen TB, Jensen PØ, et al. Modelling of ciprofloxacin killing enhanced by hyperbaric oxygen treatment in Pseudomonas aeruginosa PAO1 biofilms. PLoS ONE (2018): e0198909. https://doi.org/10.1371/journal.pone.0198909

  4. Memar MY, Yekani M, Alizadeh N, et al. Hyperbaric oxygen therapy: antimicrobial mechanisms and clinical application for infections. Biomedicine & Pharmacotherapy, Volume 109, 2019, Pages 440-447, ISSN 0753-3322, https://doi.org/10.1016/j.biopha.2018.10.142.

  5. Delasotta LA, Hanflik A, Bicking G, et al. Hyperbaric oxygen for osteomyelitis in a compromised host. Open Orthop J. 2013;7:114–117. Published 2013 May 3. doi:10.2174/1874325001307010114

  6. Ezra N, Dang K, Heuser G. Improvement of attention span and reaction time with hyperbaric oxygen treatment in patients with toxic injury due to mold exposure. Eur J Clin Microbiol Infect Dis. 2011;30(1):1–6. doi:10.1007/s10096-010-0937-8

  7. Çimşit M, Uzun G, & Yıldız S (2009) Hyperbaric oxygen therapy as an anti-infective agent. Expert Review of Anti-infective Therapy, 7:8, 1015-1026, DOI: 10.1586/eri.09.76

  8. Kaye D. Effect of hyperbaric oxygen on Clostridia in vitro and in vivo. Proc Soc Exp Biol Med 1967; 124:360.

Cerebral palsy:

  1. Mayo Clinic. (2023, December 2). Hyperbaric Oxygen Therapy.
    Retrieved from: https://www.mayoclinic.org/tests-procedures/hyperbaric-oxygen-therapy/about/pac-20394380
  2. McDonagh, M., Carson, S., Ash, J., Russman, B.S., Stavri, P.Z., Krages, K.P., and Helfand, M. (2023, September). Hyperbaric Oxygen Threapy for Brain Injury, Cerebral Palsy, and Stroke: Summary. AHRQ Evidence Report Summaries. Agency for Healthcare Research and Quality.
    Retrieved from: https://www.ncbi.nlm.nih.gov/books/NBK11904/
  3. Grice, E. (2006, April 10). Oxygen Therapy Gave us Back our Child. The Telegraph.
    Retrieved from: https://www.telegraph.co.uk/news/health/alternative-medicine/3338168/Oxygen-therapy-gave-us-back-our-child.html
  4. Laureau, J., Pons, C., Letellier, G., and Gross, R. (2022). Hyperbaric Oxygen in Children with Cerebral Palsy: A Systematic Review of Effectiveness and Safety. PLoS One. 17(10), e0276126. doi: 10.1371/journal.pone.0276126.
    Retrieved from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9565562/
 

HBOT and Fibromyalgia:

  1. Hadanny A, Bechor Y, Catalogna M, et al. Hyperbaric oxygen therapy can induce neuroplasticity and significant clinical improvement in patients suffering from fibromyalgia with a history of childhood sexual abuse-randomized controlled trial. Front Psychol. 2018;9:2495. Published 2018 Dec 17. doi:10.3389/fpsyg.2018.02495
  2. Efrati S, Hadanny A, Daphna-Tekoah S, et al. Recovery of repressed memories in fibromyalgia patients treated with hyperbaric oxygen – case series presentation and suggested bio-psycho-social mechanism. Front Psychol. 2018;9:848. Published 2018 May 29. doi:10.3389/fpsyg.2018.00848
  3. Efrati S, Golan H, Bechor Y, et al. Hyperbaric oxygen therapy can diminish fibromyalgia syndrome–prospective clinical trial. PLoS One. 2015;10(5):e0127012. Published 2015 May 26. doi:10.1371/journal.pone.0127012

 

HBOT and Cancer:

  1. Thom SR, Bhopale VM, Yang M. Microparticle-induced vascular injury in mice following decompression is inhibited by hyperbaric oxygen: effects on microparticles and interleukin-1. Journal of Applied Physiology, Volume 126, 2019

  2. Lu QZ, Li X, Ouyang J, et al. Further application of hyperbaric oxygen in prostate cancer. Med Gas Res. 2019;8(4):167–171. Published 2019 Jan 9. doi:10.4103/2045-9912.248268

  3. Lu QZ, Li X, Ouyang J, et al. Further application of hyperbaric oxygen in prostate cancer. Med Gas Res. 2019;8(4):167–171. Published 2019 Jan 9. doi:10.4103/2045-9912.248268
  4. Yahara K, Ohguri T, Udono H, et al. Radiotherapy using IMRT boosts after hyperbaric oxygen therapy with chemotherapy for glioblastoma. J Radiat Res. 2017;58(3):351–356. doi:10.1093/jrr/rrw105

  5. Choudhury R. Hypoxia and hyperbaric oxygen therapy: a review. Int J Gen Med. 2018;11:431–442. Published 2018 Nov 20. doi:10.2147/IJGM.S172460

  6. Wang YG, Long J, Shao DC, et al. Hyperbaric oxygen inhibits production of CD3+ T cells in the thymus and facilitates malignant glioma cell growth. J Int Med Res. 2018;46(7):2780–2791. doi:10.1177/0300060518767796